Registration Dossier

Administrative data

Description of key information

No dedicated studies are available for the evaluation of the irritating potential of HFC 125.  However, acute exposure up to 800000 ppm HFC-125 and repeated exposure up to 50000 ppm HFC 125 did not show signs of eye, skin or respiratory irritation. 

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Justification for classification or non-classification

HFC-125 can be considered as a non-irritating substance and no classification is deemed necessary.