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EC number: 215-239-8 | CAS number: 1314-62-1
Acute oral toxicity: LD50 = 467 mg/kg bw (OECD 401; GLP; female rats)
Acute inhalation toxicity: LC50 > 4.3 mg/L air (analytical) (OECD 436; GLP)
Acute dermal toxicity: LD50 > 2500 mg/kg bw (OECD 402; GLP)
Acute toxicity, oral
Divanadium pentaoxide in three different grades (i.e. analytical-pulverized, technical-fused, technical- pulverised) is harmful if swallowed (LD50≥ 221 < 2000 mg/kg b. w. p. o.) based on results of acute oral toxicity studies in the rat.
Acute toxicity, inhalative
Divanadium pentaoxide in three different grades (i.e. analytical-pulverized, technical-fused, technical- pulverised) is harmful if inhaled (LC50(4h) ≥ 2.21 < 5 mg/L) based on results of acute inhalation toxicity studies in the rat.
Acute toxicity, dermal
No acute toxicity was observed in rats after dermal administration of up to 2500 mg V2O5/kg b.w. in three different grades (i.e. analytical-pulverised, technical-fused, technical-pulverised).
The following information of V2O5 powder (analytical grade) is taken into account for the hazard / risk assessment:
Acute toxicity - oral: (LD50: 467 mg/kg b.w. p.o.)
Acute toxicity - inhalation: harmful (LD50: 4.3 mg/L)
Acute toxicity - dermal: non-toxic (LD50: > 2500mg/kg b.w. p.o.)
Oral toxicity According to EC Regulation 1272-2008, divanadium pentaoxide need to be classified for acute oral toxicity study as follows:
analytical grade - pulverised: Category 4 (LD50≥ 467mg/kg b.w. p.o.), H302: Harmful if swallowed
technical grade - fused: Category 4 (LD50≥ 658mg/kg b.w. p.o.), H302: Harmful if swallowed
technical grade - pulverized: Category 3 (LD50≥221 mg/kg b.w. p.o.), H301: Toxic if swallowed
According to EC Regulation 1272/2008, divanadium pentaoxide in three different grades (i.e. analytical-pulverized) need to be classified as Category 4, H 332: Harmful if inhaled.
Acute toxicity, dermal
No acute toxicity was observed after dermal administration of up to 2500 mg V2O5 /kg b.w. in rats in three different grades (i.e. analytical-pulverised). According to EC Regulation 1272 /2008, V2O5 can be classified as relatively non-toxic based on results in acute dermal toxicity studies in the rat.
Based on human data, exposure to divanadium pentaoxide may result in respiratory irritation (see Section 7.3). Thus, criteria for classification in STOT-SE Category 3 - respiratory tract irritation are met. According to the EC Regulation 1272/2008, divanadium pentaxoide is classified STOT SE Category 3: H335: May cause respiratory irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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