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EC number: 203-458-1 | CAS number: 107-06-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Tracer Study (14C-labeled solution)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2-dichloroethane
- EC Number:
- 203-458-1
- EC Name:
- 1,2-dichloroethane
- Cas Number:
- 107-06-2
- Molecular formula:
- C2H4Cl2
- IUPAC Name:
- 1,2-dichloroethane
- Details on test material:
- radiolabelled material was received from New England Nuclear, Boston, USA and was held under refrigerated conditions until used. The position of the radiolabelled atom was 1,2-14C, molecular weight was 98.96.
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
no data available - Radiolabelling:
- yes
Sampling and analysis
- Details on sampling:
- Control water: 0 and 28 days
concentration of radiolabelled 1,2.dichloroethane in water: 1, 2, 4, 7, 10, 14, 21 and 28 days of exposure
accumulation of radiolabelled 1,2.dichloroethane by bluegill: 1, 2, 4, 7, 10, 14, 21 and 28 days of exposure
and on day 1, 2, 4 and 7 of depuration for analysis of whole body residues
Test solutions
- Vehicle:
- no
- Details on preparation of test solutions, spiked fish food or sediment:
- The stock solution was prepared by transferring the contents of the sealed vials to a laboratory flask and diluted with 200 mL of pesticide grade acetone. Nominal concentration was 100 µg/L.
Test organisms
- Test organisms (species):
- Lepomis macrochirus
- Details on test organisms:
- Three populations of bluegill sunfish were maintained in the holding facilities for a minimum of 30 days prior to initiation of the test (source: commercial fish farmer in Connecticut, USA). Mean wet weights of fish were 0.37 +/- 0.18 to 0.94 +/- 0.34 and mean standard lengths ranging from 25 +/- 3mm to 32 +/- 4mm. Fish mortality was less than 3% during the acclimation period. One hundred bluegills were transferred intoo each aquarium. The fish were fed a dry pelleted food ad libitum on alternating days throughout the study and fecal material was siphoned from the aquaria when deemed necessary.
Study design
- Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 14 d
- Total depuration duration:
- 7 d
Test conditions
- Hardness:
- 35 mg/L as CACO3
- Test temperature:
- 16 °C +/- 1 °C
- pH:
- 7.1
- Dissolved oxygen:
- > 60 % of saturation
- TOC:
- no data available
- Salinity:
- no data available
- Details on test conditions:
- Glass aquaria measuring 40 by 20 by 25 (length by with by height); test aquaria were maintained in a water bath (ambient temperature, 16+/- 1°C); water temperature was measured daily; due to the high volatility of the chemicals aeration of the aquaria water was not used; dissolved oxygen concentration was measured periodically during the study. A chemical introduction system, comprised of an injectormechanism and a 50 mL gas tight glass syringe, was calibrated to introduce the desired volume of stock solution. To initiate the test, the syringe containing 50 mL of stock solution was positioned so that with each cycling of the diluter, the calibrated volume of stock (52 µL) was thoroughly mixed with 500 mL of diluent water upon introduction to the test aquarium (flow through system).
- Nominal and measured concentrations:
- 95.7 µg/l
- Reference substance (positive control):
- not specified
- Details on estimation of bioconcentration:
- Exposure period was continuos until apparent equilibrium between concentrations in the fish tissue and the exposure water was observed. Following the observation, the remaining fish were transferred into an aquarium through which test item free well water flowed at a rate equivalent to that during exposure. This depuration period was continued for 7 days so that the half life could be determined.
Results and discussion
Bioaccumulation factor
- Key result
- Conc. / dose:
- 95.7 µg/L
- Temp.:
- ca. 16 °C
- Type:
- BCF
- Value:
- 2 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 14 d
- Calculation basis:
- steady state
Depuration
- Key result
- Elimination:
- yes
- Parameter:
- DT50
- Depuration time (DT):
- 2 d
- Details on kinetic parameters:
- no data available
- Metabolites:
- no data available
- Results with reference substance (positive control):
- no data available
- Details on results:
- no data available
- Reported statistics:
- no data available
Any other information on results incl. tables
BCF related to whole fish; t1/2 (tissue) >1-<2 days.
Measured and calculated BCFs of 2 and 3.4 (logBCF = 0.3 and
0.53, respectively) have been reported.
The equation log BCF = 0.76 x logP - 0.23 is proposed for
the estimation of the bioconcentration factor from the
partition coefficient.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- As a total result of the study, the BCF of 1,2-dichloroethane can be stated with BCF = 2
- Executive summary:
A study to determine the bioconcentration of 1,2 -dichloroethane in bluegill sunfish (Lepomis macrochirus) was conducted with the nominal concentration of 100 µg test item/L under flow-through conditions using 14C labelled material. An untreated control was run in parallel. The uptake phase was 14 days, the depuration phase lasted 7 days. Fish and water samples were taken at the same time and analysed for radioactivity and 1,2 -dichlorethane to derive the uptake and depuration constants as wellas the bioconcentration factor in the state of equilibrium between uptake and elimination.
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