Ethyl acrylate

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given: study report which meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1958

Report date:

1958

Materials and methods

Principles of method if other than guideline:

BASF test:
Four groups of 5 mice per dose were treated intraperitoneally with preparations of the test substance in 5 % traganth, respectively. Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form. On the basis of the observed lethality, the LD50 value was estimated or determined using a graphical evaluation of the dose response curve on probability paper.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl acrylate

EC Number:

205-438-8

EC Name:

Ethyl acrylate

Cas Number:

140-88-5

Molecular formula:

C5H8O2

IUPAC Name:

ethyl acrylate

Details on test material:

- Name of test material (as cited in study report): Ethyl acrylate
- Physical state: liquid
- Analytical purity: no data

Test animals

Species:

mouse

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Roessling

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

other: 5 % traganth

Doses:

462, 732, 1162 and 1881 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations: after 1 h, 24 h, 48 h, and 7 d
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 554 mg/kg bw

Mortality:

The observed mortalities were 1/5, 4/5, 5/5 and 5/5 in the 462, 732, 1162 and 1881 mg/kg bw dose groups, respectively.

Clinical signs:

Dose level- 462 mg/kg: Immediately after administration, ruffled fur and swollen belly was observed, no further symptoms.
Dose level- 762 mg/kg: ruffled fur, fast respiration and imbalance was observed.
Dose level- 1162 mg/kg: ruffled fur, swollen belly, fast respiration and staggering was observed.
Dose level- 1881 mg/kg: Immediately after administration, face down position, light convulsions and death occured.

Gross pathology:

Dose level- 1162 mg/kg: Medulla renalis of kidney was congested and autolysed. One lung was also congested.
Dose level- 732 and 462mg/kg: One lung was filled with fluid and haemorrhagic.