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EC number: 205-438-8 | CAS number: 140-88-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The skin sensitising potential of Ethyl acrylate was investigated in a Local Lymphnode Assay conducted according to OECD guideline 429 and GLP regulations (BAMM 2006). The application of the test substance at concentrations of 2.5, 5, 10, 25 or 50 % w/v in acetone : olive oil (4:1) resulted in an increase in isotope incorporation which was greater than 3-fold at the 50 % w/v concentration. Consequently, the test substance was shown to be a potential skin sensitiser. The concentration giving rise to a 3 fold increase in lymphocyte proliferation (EC3) was calculated to be 36.8 % w/v (9200 μg/cm2), indicative of a sensitiser of weak potency.
Several older studies in guinea pigs and mice gave ambigious or contradictory responses. Hence, the classification was based on the LLNA by BAMM (2006).
In the Freund’s complete adjuvant test, ethyl acrylate showed a sensitizing reaction in 7 of 8 animals, whereas in the guinea pig maximization test no positive reaction was found (Van der Walle et al., 1982). Guinea pigs sensitized to ethyl acrylate exhibited cross-sensitization to challenges with several other acrylates (Van der Walle and Bensink, 1982). A Mouse Ear Swelling Test (MEST) and a Local Lymph Node Assay (LLNA) were conducted in B6C3F1 mice (NTP, 1994). In the MEST, mice were treated with a maximal non-irritating concentration (MNC) of ethyl acrylate as well as 0.1 and 0.3 times the MNC for 3 consecutive days. Following a four-day resting period, a challenge was made with a minimal irritating concentration (MIC) of ethyl acrylate. Ethyl acrylate did not exhibit contact hypersensitivity in this assay. For the LLNA, mice were treated with the MIC, the MNC, or 0.5 times the MNC for 3 consecutive days. After 1 day of rest, tritiated thymidine was injected into the animals and 5 hours later lymph nodes were dissected and tritium uptake determined. No increase in response from controls was noted in the LLNA assay.
Migrated from Short description of key information:
After repeated skin contact with Ethyl acrylate sensitization is possible.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
There is no information available on the potential for EA to produce respiratory sensitisation in animals.
Justification for classification or non-classification
EU classification according to Annex I of Directive 67/548/EEC: Xi, R43
GHS/CLP classification:
GHS UN rev.4, 2011 - Category 1B
Regulation (EC) No 1272/2008 - Category 1
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