Ethyl acrylate

Toxicity to reproduction

Administrative data

Endpoint:

fertility, other

Remarks:

based on test type (migrated information)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well documented study report, acceptable with restrictions

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1986

Materials and methods

Principles of method if other than guideline:

Five-week-old rats (10/sex/group) received oral doses of ethyl acrylate in corn oil 5 days per week for 13 weeks. Animals were assigned to control or treatment groups according to a random number table. Animals were observed twice daily for clinical signs and weighed weekly. Necropsies were performed on all animals. Tissues, including the prostate/testes (males) and ovaries/uterus (females) were examined histologically from all control and high dose animals.

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl acrylate

EC Number:

205-438-8

EC Name:

Ethyl acrylate

Cas Number:

140-88-5

Molecular formula:

C5H8O2

IUPAC Name:

ethyl acrylate

Details on test material:

- Name of test material (as cited in study report): Ethyl acrylate
- Analytical purity: 99 % and 99.5 % for lot. No. 37201 and 343029, respectively.
- Lot/batch No.: 37201 and 343029
- Stability under test conditions: Contained 15 ppm of the monoethyl ether of hydroquinone as an inhibitor.
- Storage condition of test material: stored at -20°C during the studies

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on exposure:

see 7.5.1

Details on mating procedure:

not applicable

Analytical verification of doses or concentrations:

yes

Details on analytical verification of doses or concentrations:

see 7.5.1

Duration of treatment / exposure:

13 weeks

Frequency of treatment:

5 days/week for 13 weeks

Doses / concentrations

Remarks:

Doses / Concentrations:
7, 14, 28, 55, or 110 mg/kg bw (0.7, 0.14, 0.28, 0.55, and 1.1 % solution in corn oil; 10 mL/kg bw)
Basis:
actual ingested

No. of animals per sex per dose:

10

Control animals:

yes, concurrent vehicle

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:

NOAEL

Effect level:

110 mg/kg bw/day (actual dose received)

Sex:

male/female

Basis for effect level:

other: no effects on reproductive organs

Results: F1 generation

Effect levels (F1)

Remarks on result:

not measured/tested

Overall reproductive toxicity

Reproductive effects observed:

not specified

Any other information on results incl. tables

Data on reproductive organ toxicity (testes weights as well as information on gross and microscopic pathology for testes, prostate, ovaries, and uteri) were derived from a 3 month study by the oral route ( EA, 5 days/week by gavage, 10 animals/sex/dose level) with Fischer rats according to the NTP protocol which is similar to OECD guideline 408. No effects were observed at the highest dose tested (110 mg/kg bw/day).