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Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
other: Summary of published information
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Summary of published information for sulphuric acid.

Data source

Reference
Reference Type:
secondary source
Title:
SIDS Initial Assessment Report for 11th SIAM
Author:
OECD
Year:
2001
Bibliographic source:
UNEP Publications

Materials and methods

Study type:
other: summary of health effects
Endpoint addressed:
acute toxicity: inhalation
repeated dose toxicity: inhalation
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The SIDS summarises data on the human exposure of sulphuric acid.
GLP compliance:
no
Remarks:
: not applicable

Test material

Constituent 1
Chemical structure
Reference substance name:
Sulphuric acid
EC Number:
231-639-5
EC Name:
Sulphuric acid
Cas Number:
7664-93-9
Molecular formula:
H2O4S
IUPAC Name:
sulfuric acid

Method

Details on study design:
The OECD SIDS briefly summarises the available data on the effects of human exposure to sulphuric acid

Results and discussion

Results:
Inhalation exposure to sulphuric acid is known to cause effects on the respiratory tract and teeth.

Any other information on results incl. tables

Acute inhalation exposure to sulphuric acid aerosols causes a range of effects in the respiratory system including decrease in particle clearance rates at lower concentrations ( 1.0 mg/m3) to changes in lung function (>1.0 mg/m3).  Asthmatics and those with hyper-reactive airways appear more sensitive to the broncho-constrictive effects of the aerosol. Repeated exposure to higher concentrations of aerosol (>3.0 mg/m3) has been reported to cause damage to the incisors.

Applicant's summary and conclusion

Conclusions:
Inhalation exposure to sulphuric acid is known to cause effects on the respiratory tract and teeth.
Executive summary:

Due to the rapid reaction of sulphur trioxide with atmospheric moisture, exposure to sulphur trioxide will not occur. The effects of occupational exposure to mists of sulphuric acid generated by this reaction are discussed.

Acute inhalation exposure to sulphuric acid aerosols causes a range of effects in the respiratory system including decrease in particle clearance rates at lower concentrations ( 1.0 mg/m3) to changes in lung function (>1.0 mg/m3).  Asthmatics and those with hyper-reactive airways appear more sensitive to the broncho-constrictive effects of the aerosol. Repeated exposure to higher concentrations of aerosol (>3.0 mg/m3) has been reported to cause damage to the incisors.

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