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Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published non-standard study

Data source

Reference
Reference Type:
review article or handbook
Title:
Effects of sulfuric acid aerosols on pulmonary functions of guinea pigs
Author:
Silbaugh et al
Year:
1981
Bibliographic source:
J. Toxicol. Environ. Health, 7, 339-352

Materials and methods

Type of study / information:
Airway response in exposed guinea pigs
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Invetigation of airway response in guinea pigs exposed to sulphuric acid by inhalation
GLP compliance:
no
Remarks:
older published study

Test material

Constituent 1
Chemical structure
Reference substance name:
Sulphuric acid
EC Number:
231-639-5
EC Name:
Sulphuric acid
Cas Number:
7664-93-9
Molecular formula:
H2O4S
IUPAC Name:
sulfuric acid
Details on test material:
Sulphuric acid

Results and discussion

Any other information on results incl. tables

Eight exposed animals exhibited increased total pulmonary resistance and decreased dynamic compliance. Four of these 8 responsive animals died during exposure. All other H2SO4-exposed animals exhibited no major differences from controls and were termed nonresponsive. The proportion of responsive to non-responsive animals increased with exposure concentration but the magnitude of pulmonary function change was similar for all responsive animals regardless of concentration. Compared to nonresponders, responsive animals had higher preexposure values of tidal transpulmonary pressure excursions and total pulmonary resistance and lower values of dynamic compliance. Preexposure transpulmonary pressure excursions were positively correlated with minute volume only for nonresponsive animals; transpulmonary pressure excursions were positively correlated with total pulmonary resistance in responsive animals.

Applicant's summary and conclusion

Executive summary:

Exposure of guinea pigs to sulphuric acid aerosols by inhalation revealed an all-or-none response, with increased resistance and reduced compliance seen in a proportion of animals. It is postulated by the authors that sensitivity may be linked to pre-exposure.

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