Registration Dossier
Registration Dossier
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EC number: 200-835-2 | CAS number: 75-05-8
Biodegradation in soil
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in soil
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Limited information available
- Principles of method if other than guideline:
- Estimated from data on aqueous aerobic biodegradation
- Test type:
- not specified
- DT50:
- > 168 - < 672 h
- Remarks on result:
- other: Estimated
- Executive summary:
A half-life range for acetonitrile in soil of 168 -672 hours (1 -4 weeks) has been estimated from data on aqueous aerobic biodegradation (Howard et al. 1991).
- Endpoint:
- biodegradation in soil
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Limited information available
- Test type:
- not specified
- Executive summary:
The soil bacterium Aeromonas sp. BN 7013 and soil fungus Fusarium solani also grow using acetonitrile (Harper, 1977; Kuwahara et al. 1980).
- Endpoint:
- biodegradation in soil
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Limited information available. Design does not meet guidelines.
- Principles of method if other than guideline:
- No information available.
- Test type:
- not specified
- Initial conc.:
- 10 other: mg/ml
- Based on:
- test mat.
- % Degr.:
- 14
- Sampling time:
- 3 h
- % Degr.:
- 52
- Sampling time:
- 8 h
- DT50:
- 7 h
- Remarks on result:
- other: Nocardia rhodochrus in barnyard soil
- Executive summary:
Acetonitirile was used as the sole carbon and nitrogen source by Pseudomonas putida in soil and by Nocardia rhodochrus in barnyard soil (10 mg acetonitrile/ml); metabolites included ammonia, acetamide and acetic acid (Digeronimo and Antoine, 1976; Nawoz et al. 1989). In the study using Nocardia sp. 14% degradation occurred in 3 hours and 52% in 8 hours; the half-life was 7 hours.
- Endpoint:
- biodegradation in soil: simulation testing
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is readily biodegradable
Referenceopen allclose all
A half-life range in soil of 168 -672 hours (1 -4 weeks) has been estimated from data on aqueous aerobic biodegradation (Howard et al. 1991).
The soil bacterium Aeromonas sp. BN 7013 and soil fungus Fusarium solani also grow using acetonitrile (Harper, 1977; Kuwahara et al. 1980).
Acetonitrile was used as the sole carbon and nitrogen source by Pseudomonas putida in soil and by Nocardia rhodochrus in barnyard soil (10 mg acetonitrile/ml); metabolites included ammonia, acetamide and acetic acid (Digeronimo and Antoine, 1976; Nawoz et al. 1989). In the study using Nocardia sp. 14% degradation occurred in 3 hours and 52% in 8 hours; the half-life was 7 hours.
Description of key information
In the study using Nocardia sp. 14% degradation occurred in 3 hours and 52% in 8 hours; the half-life was 7 hours. A half-life range for acetonitrile in soil of 168 -672 hours (1 -4 weeks) has been estimated from data on aqueous aerobic biodegradation (Howard et al. 1991). A waiver from further testing in soil is requested.
Key value for chemical safety assessment
Additional information
A half-life range for acetonitrile in soil of 168 -672 hours (1 -4 weeks) has been estimated from data on aqueous aerobic biodegradation (Howard et al. 1991).
Acetonitirile was used as the sole carbon and nitrogen source by Pseudomonas putida in soil and by Nocardia rhodochrus in barnyard soil (10 mg acetonitrile/ml); metabolites included ammonia, acetamide and acetic acid (Digeronimo and Antoine, 1976; Nawoz et al. 1989). In the study using Nocardia sp. 14% degradation occurred in 3 hours and 52% in 8 hours; the half-life was 7 hours.
The soil bacterium Aeromonas sp. BN 7013 and soil fungus Fusarium solani also grow using acetonitrile (Harper, 1977; Kuwahara et al. 1980).
A waiver from further testing in soil is requested on the basis that it is not scientifically justified because acetonitrile is readily biodegradable in reliable screening tests.
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