Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 200-835-2 | CAS number: 75-05-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Limited information available
- Principles of method if other than guideline:
- Estimated from the LogKow
- GLP compliance:
- no
- Media:
- soil
- Type:
- Koc
- Value:
- 0.3 - 16 L/kg
- Remarks on result:
- other: using the octanol-water partition coefficient, log Kow = -0.34 (Leo, 1971) and regression equations reported in Lyman (1982)
- Executive summary:
The adsorption coefficient Koc can be estimated for acetonitrile using the octanol-water partition coefficient, log Kow = -0.34 (Leo, 1971). Koc values of 0.3 - 16 were obtained using regression equations reported in Lyman (1982), indicating that adsorption onto suspended solids or sediment by acetonitrile would be weak and likely to be unimportant. Leaching, on the other hand, could be significant (Howard, 1993). Sorption on to clay soils would be due to partition between the interfacial clay and the bulk solution phases, and not due to any specific bonding (Howard, 1993).
- Endpoint:
- adsorption / desorption, other
- Remarks:
- QSAR
- Type of information:
- (Q)SAR
- Remarks:
- Estimated via US EPA PCKOC software (v1.66)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- Model cited in R.7 guidance
- Principles of method if other than guideline:
- PCKOC v1.66
- Key result
- Type:
- Koc
- Value:
- 4.5 L/kg
- Executive summary:
US EPA PCKOC software (v1.66) generated an estimated Koc of 4.5 for acetonitrile.
Referenceopen allclose all
The adsorption coefficient Koc can be estimated for acetonitrile using the octanol-water partition coefficient, log Kow = -0.34 (Leo, 1971). Koc values of 0.3 - 16 L/kg were obtained using regression equations reported in Lyman (1982), indicating that adsorption onto suspended solids or sediment by acetonitrile would be weak and likely to be unimportant. Leaching, on the other hand, could be significant (Howard, 1993). Sorption on to clay soils would be due to partition between the interfacial clay and the bulk solution phases, and not due to any specific bonding (Howard, 1993).
estimated Koc of 4.5
Description of key information
Estimated Koc values for acetonitrile range from 0.3 - 16 and indicate a low potential for adsorption to soils.
Key value for chemical safety assessment
- Koc at 20 °C:
- 4.5
Additional information
The adsorption coefficient, Koc, can be estimated for acetonitrile using the octanol-water partition coefficient, log Pow = -0.34 (Leo et al., 1971), and Koc values of 0.3-16 were obtained using regression equations reported in Lyman et al (1982). EPA PCKOC software (v1.66) generated an estimated Koc of 4.5 for acetonitrile. These Koc values indicate a low potential for adsorption to soils; given the high water solubility of acetonitrile leaching to groundwater may be important when spilled on soil (Howard, 1993). Sorption on to clay soils would be due to partition between the interfacial clay and the bulk solution phases, and not due to any specific bonding (Howard, 1993).
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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