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EC number: 240-841-2 | CAS number: 16812-54-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study (OECD)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- other:
- Limit test:
- yes
Test material
- Reference substance name:
- Nickel sulfide
- EC Number:
- 234-349-7
- EC Name:
- Nickel sulfide
- IUPAC Name:
- Nickel sulfide
- Details on test material:
- - Name of test material (as cited in study report): Nickel sulfide
- Substance type: amorphous nickel sulfide, aqueos slurry
- Elemental composition: 52.4% Ni, 31.85% S
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Inc., Wilmington, MA
- Age at study initiation: adult
- Weight at study initiation: ~ 292 g (males); ~199 (females)
- Fasting period before study: night before study
- Housing: Animals were individually housed in wire mesh bottom cages in environment controlled rooms.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
-
MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose:
used a range finder - Doses:
- Range Finding Study: 100, 266, 707, 1880, 5000 mg/kg
Mortality Study: 5000 mg/kg - No. of animals per sex per dose:
- 5 male; 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: "frequently" on the day of exposure; twice daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Not reported.
Results and discussion
- Preliminary study:
- No mortality in rat groups (n=10) exposed to 5000 mg/kg at 15 days post-exposure.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- None.
- Clinical signs:
- other: Diarrhea (1/5 males; 0/5 females)
- Gross pathology:
- No noteworthy findings.
- Other findings:
- None.
Applicant's summary and conclusion
- Conclusions:
- Based on the data obtained from this study, the acute oral LD50 is considered to be greater than 5000 mg/kg bodyweight.
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