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EC number: 265-043-1 | CAS number: 64741-43-1 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C11 through C25 and boiling in the range of approximately 205°C to 400°C (401°F to 752°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985-06-11 to 1985-12-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restriction because it was conducted according to or similar to guideline study OECD TG 402.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Skin was abraded. Other deviations (initial body weights and humidity) are not considered to have had an effect on the validity of the study.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 64741-44-2
- Cas Number:
- 64741-44-2
- IUPAC Name:
- 64741-44-2
- Reference substance name:
- Straight run middle distillate
- IUPAC Name:
- Straight run middle distillate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 83-11
- Substance type: Straight run middle distillate
- Physical state: Clear, pale-yellow liquid
- CAS number: 64741-44-2
- Gravity API: 36.2
- Sulfur wt %: 0.30
- Nitrogen ppm: 80
- Boiling range (ASTM D-86 equiv) 10%: 488 °F
- Initial Boiling Point 366 °F
- End Boiling Point 735 °F
- Viscosity at 40°C cSt: 4.16
- Aniline Point °F: 171
- Composition % by MS:
olefins 2.0
aromatics 21.0
saturates 77.0
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Dutchland, Inc. , Denver, Pennsylvania
- Age at study initiation: Approximately 14 weeks of age
- Weight at study initiation: Between 2,318 grams and 2,604 grams
- Housing: Individual cages
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: At least 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 to 23
- Humidity (%): 42 to 74 relative humidity
- Photoperiod (hrs dark / hrs light): 12 hrs dark/ 12 hrs light
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- 83-11 was dosed as received
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Back of animal was exposed
- % coverage: Approximately 10%
- Type of wrap if used: Application area was wrapped with an eight-ply gauze bandage and overwrapped with Saran Wrap and Elastoplast tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Area was wiped but not washed.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg bw - Duration of exposure:
- The animals were exposed for 24 hours.
- Doses:
- An individual dose at a level of 2000 mg/kg was weighed out for each animal based upon its body weight at the study initiation.
- No. of animals per sex per dose:
- Eight animals (four male and four female) were dosed.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed hourly for the first six hours after dosing, then daily for dermal irritation and twice daily for clinical signs and mortality for a period of 14 days. Body weights were taken just prior to administration, at 7 days, and at study termination.
- Necropsy of survivors performed: Yes - Statistics:
- No data reported.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality was observed at this dose level.
- Clinical signs:
- other: No clinical signs were observed during the study.
- Body weight:
- other body weight observations
- Remarks:
- Body weights increased in both sexes over the course of the study.
- Gross pathology:
- No visible lesions were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information LD50 is greater than 2000 mg/kg Criteria used for interpretation of results: EU
- Conclusions:
- Dermal irritation observed during the study ranged from slight to moderate for erythema, oedema, atonia, desquamation, and fissuring.
Slight coriaceousness was also seen. - Executive summary:
In an acute dermal toxicity study, 4 male and 4 female albino New Zealand rabbits were dermally exposed, under occlusion, to a Straight run middle distillate for 24 hours to approximately 10% of their body surface, at 2000 mg/kg bw. No sign of systemic toxicity or mortality was observed at this dosage level. Slight to moderate dermal irritation for erythema, oedema, atonia, desquamation, and fissuring, and slight coriaceousness were observed.
The dermal LD50 was >2000 mg/kg in males and females.
This study received a Klimisch score of 1 and is classified as reliable without restriction because it was conducted according to or similar to guideline study OECD TG 402.
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