Registration Dossier
Registration Dossier
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EC number: 200-857-2 | CAS number: 75-28-5
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: human data
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Human clinical data published in peer reviewed literature. Reliability not known but contributing to weight of evidence.
Data source
Reference
- Reference Type:
- publication
- Title:
- Propane asphyxiation
- Author:
- Imami RH and Kemal M
- Year:
- 1 986
- Bibliographic source:
- The American Journal of Forensic Medicine and Pathology 7(1): 76-77
Materials and methods
- Study type:
- other: suicide by asphyxiation
- Endpoint addressed:
- acute toxicity: inhalation
- Principles of method if other than guideline:
- Case report of a suicide by propane asphyxiation.
Test material
- Reference substance name:
- Propane
- EC Number:
- 200-827-9
- EC Name:
- Propane
- Cas Number:
- 74-98-6
- Molecular formula:
- C3H8
- IUPAC Name:
- propane
- Details on test material:
- - Name of test material (as cited in study report): propane
- The subject used "utility gas" from the domestic cooking stove
Constituent 1
Method
- Type of population:
- other: intentional exposure to utility gas
- Subjects:
- - Number of subjects exposed: 1
- Sex: male
- Age: 81
- Race: white
- Other: a history of suicidal tendencies. - Route of exposure:
- inhalation
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
- Details on exposure:
- The decedent was found dead beside the stove; his head covered with a plastic bag and the stove gas was turned on.
- Examinations:
- - Other: An autopsy was performed. Blood and urine were submitted for toxicological analysis.
Results and discussion
- Results of examinations:
- The lungs showed some emphysematous bullae and the tracheobronchial tree showed some greyish-pink, mucoid material. The tracheobronchial lymph nodes were enlarged and calcified.
- Outcome of incidence:
- Suicide case; death was due to hypoxemia secondary to propane inhalation.
Any other information on results incl. tables
The retention times of the autopsy sample peaks matched those of the references and the "utility gas". Carbon monoxide and other volatile gases were not detected.
Applicant's summary and conclusion
- Conclusions:
- Death was due to hypoxemia secondary to propane inhalation.
- Executive summary:
In this suicide case, death was due to hypoxemia secondary to propane inhalation.
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