Registration Dossier

Administrative data

Description of key information

No toxicity was observed bot after oral and dermal adminbistration of vinyl laurate up to the highest requested dose of 2000 mg/kg bw. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

A group of five male and five female Sprague-Dawley rats was treated with Vinyl laurate at 2000 mg/kg by oral gavage according to OECD Guideline 401 with a 14 days observation period. No animal died during the study. No signs of toxicity were not observed in any animal. The body weight of the animals was within the range of physiological variability known for rats of this strain and age. No macroscopic findings were observed at necropsy of the animals. The LD50 (oral, rat) was determined to be > 2000 mg/kg bw.

A group of five male and five female Wistar rats was treated with Vinyl laurate at 2000 mg/kg by single dermal application according to OECD Guideline 402 with a 14 days observation period. One animal died during the first day after application. Only slight signs of toxicity were not observed in the surviving animals like flat/hunched posture, piloerection Diarrhea, chromodacryorrhoea (snout) and/or ptosis. The animals recovered from the symptoms between day 2 and 4 of the study. Scales and scrabs were seen in the treated skin area of several animals during the observation period. The body weight of the animals was within the range of physiological variability known for rats of this strain and age. No macroscopic findings were observed at necropsy of the animals. The LD50 (dermal, rat) was determined to be > 2000 mg/kg bw.

Justification for classification or non-classification

As there was no effect in both dermal and oral administration of the test item, no classification is necessary.