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EC number: 218-414-7 | CAS number: 2146-71-6
The effects of Vinyl laurate on the possible health hazards likely to arise from repeated exposure over a relatively limited period of time were assessed in a OECD 422 study. . In addition this combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in the Han Wistar rat provides information on possible effects on male and female reproductive performance such as gonadal function, mating behavior, conception, development of the conceptus and parturition.
Vinyl laurate was administered to male rats for at least 28 days and to female rats for 14 days prior to pairing, through the pairing and gestation periods until the F1 generation reached day 4 post partum. The following dose levels were applied:
Group 1: 0 mg/kg body weight/day (control group), Group 2: 50 mg/kg body weight/day, Group 3: 250 mg/kg body weight/day, Group 4: 1000 mg/kg body weight/day. A standard dose volume of 5 mL/kg body weight with a daily adjustment to the actual body weight was used. Control animals were dosed with the vehicle alone (corn oil).
All parent animals survived until the scheduled necropsy. No clinical signs or observations were noted for any male or female in any groups during the duration of the study. No test item-related findings were noted in the Functional Observational Battery. Mean food consumption and body weights were note affected by treatment with the test item in the males and females during the study. No test item-related effects were noted from the clinical laboratory investigations. All female mated. No effects were noted in the reproduction and breeding data. No test item-related effects were noted in the organ weights. No test item-related macroscopical or histopathological findings were observed.
No test item-related findings at first litter check and during lactation were noted. Pup weights to day 4 post partumwere unaffected by treatment with the test item. No test item-related macroscopical findings were observed in the pups. .
The general NOEL (No Observed Effect Level) was considered to be 1000 mg/kg body weight/day.
The NOEL (No Observed Effect Level) for reproduction/developmental toxicity was also considered to be1000 mg/kg body weight/day.
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