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EC number: 218-414-7 | CAS number: 2146-71-6
Vinyl laurate was analyzed for effects on the pregnant rat and development of the embryo and fetus consequent to exposure of the female to the test item from day 6 post coitum (implantation) to day 20 post coitum (the day prior to Caesarean section) according to OECD Guideline 414.
Four groups of females were treated by gavage with Vinyl laurate once daily at dose levels of:
Group 1: 0 mg/kg body weight/day (control group)
Group 2: 50 mg/kg body weight/day
Group 3: 250 mg/kg body weight/day
Group 4: 1000 mg/kg body weight/day
A standard dose volume of 5 mL/kg body weight with a daily adjustment to the actual body weight was used. Control animals were dosed with the vehicle alone (corn oil).
All dams survived until the scheduled necropsy. No clinical symptoms related to treatment with the test item were noted during the study. Mean food consumption, body weight, body weight gain and corrected body weight gain (corrected for the gravid uterus weight) were not affected by treatment with the test item in any dose group.The relevant reproduction data (post-implantation loss and the mean number of fetuses per dam) were not affected by treatment with the test item. No macroscopical findings were noted during necropsy of the dams in any group.
During the external examination of the fetuses, no abnormal findings were noted in any group.No test item-related effects on fetal sex ratios were noted in any dose group. Mean fetal body weight did not reveal any test item-related effect. No findings were observed which were considered to be test item-related. No findings, which were considered to be test item-related, were observed during examination of fetal skeletons and cartilages.
Based on the results of this study, the NOEL (No Observed Effect Level) for maternal and fetal organisms was considered to be 1000 mg/kg body weight/day. Under the conditions of this study, Vinyl laurate did not reveal any teratogenic potential up to and including 1000 mg/kg body weight/day.
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