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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

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Description of key information

Oncorhynchus mykiss (freshwater species): 96h-LC50=5540 mg/L (nominal) 
Alburnus alburnus (saltwater species): 96 h LC50=11000 mg/L (nominal)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
LC50
Effect concentration:
5 540 mg/L

Marine water fish

Marine water fish
Dose descriptor:
LC50
Effect concentration:
11 000 mg/L

Additional information

Several studies on the acute toxicity of acetone towards different fish are available. No tests according to standard guidelines for short-term toxicity to fish (e.g. OECD 203) are available. Only one study was conducted comparable to guideline with analytical monitoring of the test substance concentration. Two other studies were performed under flow-through conditions (24 h test duration) and semi-static conditions (14 d test duration), respectively. Furthermore, reliable results are available from studies using 48 h exposure periods; although this studies are not in conformity to current guidelines (exposure period 48 h instead of 96 h), they can at least be used as a hint on the acute toxicity of acetone to fish. A comparison of all available data, indicate that although several studies were conducted under static conditions and without analytical monitoring, the results were comparable. Therefore it can be assumed that the moderate volatility based on the experimentally determined Henry's Law constant is of little importance for the interpretation of the results.

The 96h-LC50-values of three consecutive studies conducted comparable to OECD TG 203 under flow.through conditions with Pimephales promelas were in the range between 6210 and 8120 mg/L (geometric mean: 7163 mg/L) based on measured concentration and the 96h-EC50 was determined to be in the range between 6290 and 8120 mg/l (geometric mean: 7057 mg/L. In a further study conducted under flow-through conditions and using rainbow trout fingerlings as test organisms, a 24 h LC50=6100 mg/L (nominal) was determined. Although the exposure period (24 h) is not in compliance with current guidelines, the result, however, can at least be used as a hint on the acute toxicity of acetone towards Salmo gairdneri. Furthermore, a 96h-LC50=5540 mg/L (nominal) was found for Oncorhynchus mykiss in a study performed comparable to OECD TG 203. A 14d-LC50=6368 mg/L (nominal; prolonged fish toxicity study) was determined for Poecilia reticulata in a semi-static test. A 96 h LC50=11000 mg/L was determined for the brackish fish Alburnus alburnus in closed system.