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Diss Factsheets
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EC number: 204-673-3 | CAS number: 124-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity of adipic acid to fish (Danio rerio) was assessed in a static bioassay according to a national standard method. After 96 hours of exposure, a LC0 of > 1000 mg/L was obtained (Bayer, 1991).
Adipic acid was tested with respect to the acute toxicity towards invertebrates (Dapnia magna) in a static test yielding in an 48 h-EC50 of 46 mg/L (MITI, 1997).
Concerning the toxicity to algae, the fresh water alga Pseudokirchnerella subcapitata was exposed to adipic acid for 72 hours. The experiment was conducted according to OECD Guideline 201 (Alga, Growth Inhibition Test). The test gave a 72h-EC50 value for effects on growth rate of 59 mg/L and a 72h-EC10 of 41 mg/L (MITI, 1997).
The long-term toxicity test of adipic acid towards aquatic invertebrates (Dapnia magna) was investigated in a reproduction test according OECD Guideline 211. After 21 days of exposure a NOEC-reproduction of 6.3 mg/L was determined (MITI, 1997). To assess the toxicity towards microorganisms, a respiratory inhibition test with activated sludge was performed. After 3 h an EC50 and an EC10 of higher than 100 mg/L, respectively, and a NOEC >= 100 mg/L was observed. (Currenta, 2019).
Additional information
Adipic acid is a weak to medium strong acid and partly dissociates in water causing a pH shift (pKa1: 4.34; pKa2: 5.44). The tolerance of water organisms towards pH is diverse. Recommended pH values for test species listed in OECD guidelines are between 6 and 9.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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