Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 204-673-3 | CAS number: 124-04-9
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: case reports
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- SIDS Initial Assessment Report for SIAM 18 for Adipic acid
- Author:
- OECD/SIDS
- Year:
- 2 004
- Bibliographic source:
- published by UNEP
- Report date:
- 2004
Materials and methods
- Type of sensitisation studied:
- respiratory
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- no guideline followed
Test material
- Reference substance name:
- Adipic acid
- EC Number:
- 204-673-3
- EC Name:
- Adipic acid
- Cas Number:
- 124-04-9
- Molecular formula:
- C6H10O4
- IUPAC Name:
- adipic acid
- Reference substance name:
- Hexanedioic acid
- IUPAC Name:
- Hexanedioic acid
- Details on test material:
- Purity is 99.8%
Constituent 1
Constituent 2
Method
- Type of population:
- occupational
Results and discussion
- Results of examinations:
- Despite the wide use of adipic acid, only very few cases of skin or respiratory tract reactions are reported:
A positive patch test reaction to adipic acid (probably 1 % in alcoholic solution) was reported in a 51-year-old machine repairman with a 3- to 4-year history of work-related dermatitis of the hands and other exposed sites when working with powders in the synthesis of polyesters (Guin 2001).
Delayed cutaneous hypersensitivity to adipic acid was reported in a patch test (100 %) with a laboratory worker in a factory producing polyester resins. No further details are available in this case (Malten and Zielhuis 1964).
Two cases of bronchial asthma were reported in workers of a pharmaceutical factory coming into contact with spiramycin adipate powder. One of the workers developed an immediate asthmatic reaction also after inhalation of an aerosolized solution (10 mg/ml) of adipic acid. The reaction was reproducible and inhibited by previous administration of sodium cromoglycate. These findings suggested a hypersensitivity reaction to adipic acid by this patient (Moscato et al. 1984).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
