Registration Dossier
Registration Dossier
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EC number: 204-673-3 | CAS number: 124-04-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Number of animals low, purity not specified.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
- Principles of method if other than guideline:
- Adipic acid was tested as a 40% solution in corn oil. Minimum lethal dose was determined using 1-2 rabbits per group (5010 mg/kg bw one animal, 7940 mg/kg bw two animals). A 24- hour dermal exposure under occlusive conditions was conducted. Necropsy was conducted after a 14-day observation period.
- GLP compliance:
- no
- Test type:
- other:
Test material
- Reference substance name:
- Adipic acid
- EC Number:
- 204-673-3
- EC Name:
- Adipic acid
- Cas Number:
- 124-04-9
- Molecular formula:
- C6H10O4
- IUPAC Name:
- adipic acid
- Details on test material:
- Test substance purity not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- corn oil
- Duration of exposure:
- 24 hours
- Doses:
- 5010 and 7940 mg/kg
- No. of animals per sex per dose:
- 5010 mg/kg bw one animal, 7940 mg/kg bw two animals
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 7 940 mL/kg bw
Any other information on results incl. tables
No deaths occurred at 5010 mg/kg bw (0/1) or 7940 mg/kg bw
(0/2). Observations included reduced appetite and activity.
Reduced appetite and activity ( one or two days).
Applicant's summary and conclusion
- Executive summary:
No lethality was reported in rabbits following occlusive dermal administration of up to 7940 mg/kg bw of 40 % adipic acid in corn oil for 24 hours. Animals showed reduced appetite and activity and the viscera were normal at necropsy after 14 days observation period (Solutia Inc. 1975).
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