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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
supporting study

Data source

Reference
Reference Type:
review article or handbook
Title:
Einfluss der Resorptionsverfügbarkeit auf die Toxizität von Verbindungen der Schwermetalle Nickel, Chrom, Cadmium und Blei
Author:
Schneider, K. et al.
Year:
2001
Bibliographic source:
Umweltmed Forsch Prax 6 (1):15 - 24.

Materials and methods

Principles of method if other than guideline:
This literature study investigates the correlation between bioaccessibility and toxicity of compounds of the heavy metals, such as chromium compounds, with low water solubility. The publication reported the water solubility of chromium compounds as surrogate for bioaccessiblity.

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parameters
Toxicokinetic parameters:
other:
Remarks:
Cr(III) substances vary considerably in their water solubility: e.g., whereas substances like Cr(III) chloride and sulfate have water solubilities of approx. 585 g/L (25°C) and 700 g/L (35°C) respectively, Cr (III) oxide is often described as “insoluble

Applicant's summary and conclusion

Conclusions:
Cr(III) substances vary considerably in their water solubility: e.g., whereas substances like Cr(III) chloride and sulfate have water solubilities of approx. 585 g/L (25°C) and 700 g/L (35°C) respectively, Cr (III) oxide is often described as “insoluble