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EC number: 203-806-2 | CAS number: 110-82-7
Mean maternal bodyweight gain (g) selected timepoints
Days 0 to 6
Days 6 to 16
Days 6 to 21 (b)
7000 ppm (b)
# pair fed control b- ANOVA and Dunnett’s test
† significant difference from control (ANOVA and Dunnett’s test); p±0.05
* significant trend (linear contrast of means from ANOVA); p±0.05
b bwt gain on GD6-21 after correction for gravid uterus weight
The developmental toxicity of cyclohexane was assessed in Crl:CD BR rats. The animals were exposed whole-body to nominal atmospheric concentrations of 0, 500, 2000, or 7000 ppm cyclohexane vapour. For rats in the 7000 ppm group, statistically significant reductions were observed in overall and adjusted maternal body weight gain while a transient diminished or absent response to a sound stimulus was apparent at 2000 ppm. Therefore the maternal no-observed-adverse-effect concentration (NOAEC) was 500ppm (1,720 mg/m3) (based upon transient sedation) or 2000 ppm (6,880 mg/m3) (based upon significant reductions in overall and adjusted body weight gain). No compound-related evidence of developmental toxicity was observed at any test concentration, equivalent to a NOAEC of 7000 ppm (24,080 mg/m3).
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