Registration Dossier
Registration Dossier
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EC number: 932-124-4 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No studies on SFL are available.
The key study was conducted on an analogous substance and assessed the toxicity of calcium carbonate (nano) to aquatic microorganisms in a GLP study performed in accordance with OECD Guideline 209. The effect of calcium carbonate (nano) on the respiration of activated sewage sludge micro-organisms gave a 3 h EC50 of greater than 1000 mg/L. The NOEC after 3 hours exposure was 1000 mg/L.
The result from this study demonstrates that calcium carbonate is not acutely toxic to aquatic microorganisms and can be read across to SFL.
Key value for chemical safety assessment
Additional information
Rationale for read across:
SFL is primarily composed of inorganic substances. The major constituent is calcium carbonate, along with silicon dioxide and a small amount of other inorganic salts (including calcium salts) and the remainder is composed of organic plant material. None of the components of SFL carry a classification for physical chemical properties or the environment and therefore SFL is not classified as hazardous to the environment. Since the major component of SFL is calcium carbonate, it can therefore be assumed that the properties of SFL will be governed by those of calcium carbonate. It is therefore considered appropriate for this data to be used for read-across purposes and any further testing would be scientifically unjustified.
The key study [Youngs (2010)] was performed to OECD Guideline 209 and in accordance with GLP. The study assessed the toxicity of calcium carbonate (nano) to activated sewage sludge at nominal test concentrations of 10, 32, 100, 320 and 1000 mg/L. No toxic effects were seen at any concentration of calcium carbonate (nano) tested. Hence, the 3 h EC50 was >1000 mg/L and the NOEC was 1000 mg/L. Calcium carbonate (nano) is therefore not toxic to aquatic microorganisms up to a concentration of 1000 mg/L. Evidence of undissolved test material was observed in some of the test vessels suggesting that the concentrations tested exceeded the maximum solubility of calcium carbonate in water. Since this study can be read across to SFL, it is expected that SFL would also not be acutely toxic to aquatic microorganisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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