Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
long-term toxicity to fish
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.

Data source

Reference
Reference Type:
other: SNIF
Title:
Unnamed
Year:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
A mixture of: esters of C14-C15 branched alcohols with 3,5-di-t-butyl-4-hydroxyphenyl propionic acid; C15 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate; C13 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate
EC Number:
413-750-2
EC Name:
A mixture of: esters of C14-C15 branched alcohols with 3,5-di-t-butyl-4-hydroxyphenyl propionic acid; C15 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate; C13 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate
IUPAC Name:
413-750-2
Constituent 2
Reference substance name:
reaction mass of: esters of C14-C15 branched alcohols with 3,5-di-t-butyl-4-hydroxyphenyl propionic acid; C15 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate; C13 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate
IUPAC Name:
reaction mass of: esters of C14-C15 branched alcohols with 3,5-di-t-butyl-4-hydroxyphenyl propionic acid; C15 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate; C13 branched and linear alkyl 3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoate
Test material form:
not specified

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
yes
Details on test solutions:
Identity and concentration of auxiliary solvent for dispersal: Acetone :33 µL/L

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:
static
Water media type:
freshwater
Total exposure duration:
21 d
Remarks on exposure duration:
Duration is normally 14 days, but can be extended by one or two weeks in accordance with the guideline.

Test conditions

Hardness:
243 mg CaCO3/L

Results and discussion

Effect concentrationsopen allclose all
Duration:
14 d
Dose descriptor:
LC50
Effect conc.:
> 0.33 mg/L
Nominal / measured:
nominal
Conc. based on:
not specified
Basis for effect:
mortality
Duration:
21 d
Dose descriptor:
LC50
Effect conc.:
> 0.33 mg/L
Nominal / measured:
nominal
Conc. based on:
not specified
Basis for effect:
mortality
Duration:
14 d
Dose descriptor:
NOEC
Effect conc.:
0.33 mg/L
Nominal / measured:
nominal
Conc. based on:
not specified
Basis for effect:
not specified
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.33 mg/L
Nominal / measured:
nominal
Conc. based on:
not specified
Basis for effect:
other: visible abnormality
Details on results:
%Concentration loss over test: 19.2 ...
Signs of toxicity: None

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
LC50 (21d) > 0.33 mg/L
NOEC (21d) = 0.33 mg/L
Due to its low water solubility, the test substance is considered not to be toxic to fish under the conditions of the test.