Registration Dossier
Registration Dossier
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EC number: 235-186-4 | CAS number: 12125-02-9
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- not specified
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited information about test substance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Ammonia Toxicity and pH
- Author:
- Warren, K.S.
- Year:
- 1 962
- Bibliographic source:
- Nature, 195, 47-49 (1962)
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ammonium chloride
- EC Number:
- 235-186-4
- EC Name:
- Ammonium chloride
- Cas Number:
- 12125-02-9
- Molecular formula:
- ClH4N
- IUPAC Name:
- ammonium chloride
- Details on test material:
- no data
Constituent 1
Results and discussion
Any other information on results incl. tables
Memo: ammonia toxicity
Applicant's summary and conclusion
- Conclusions:
- In most biological fluids ammonia exists in two forms and the toxicity is determined primarily by the pH of the solution. Since toxicity depends on the ammonia which enters the organism, and thence the cell, it is of particular importance that cell membranes are relatively impermeable to one form (ionized ammonia), whereas the other (un-ionized ammonia) passes tissue barriers with ease.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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