Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 235-186-4 | CAS number: 12125-02-9
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- not specified
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited information.
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Levene, D.L. and Knight, A.,
- Year:
- 1 974
- Bibliographic source:
- CMA Journal, 111, 335-338 (1974)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
Test material
- Reference substance name:
- Ammonium chloride
- EC Number:
- 235-186-4
- EC Name:
- Ammonium chloride
- Cas Number:
- 12125-02-9
- Molecular formula:
- ClH4N
- IUPAC Name:
- ammonium chloride
Constituent 1
Method
- Details on exposure:
- Therapeutic agent use
Results and discussion
Any other information on results incl. tables
Ammonium chloride has been available as a therapeutic agent
in Canada since its introduction in 1925. It has been used
as a mild diuretic, an expectorant, a weight-reducing agent
and a urine-acidifying agent. As little as 100mg/kg of
ammonium chloride as a single dose may cause a fall of urine
pH to less than 5.2, a level that is bacteriostatic for many
organisms. Some commonly used agents suchas methenamine and
nitrofurantoin seem more effective in an acid environment.
The use of ammonium chloride clearly requires caution of
renal disease.
Applicant's summary and conclusion
- Conclusions:
- Ammonium chloride has been available as a therapeutic agent in Canada since its introduction in 1925. It has been used as a mild diuretic, an expectorant, a weight-reducing agent and a urine-acidifying agent. As little as 100mg/kg of ammonium chloride as a single dose may cause a fall of urine pH to less than 5.2, a level that is bacteriostatic for many organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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