Registration Dossier
Registration Dossier
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EC number: 203-786-5 | CAS number: 110-63-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Metabolites: rapidly metabolised to gamma-hydroxybutyric acid, succinic acid, and carbon dioxide. Dermal Absorption Rate (Estimated): 0.14 mg/cm2-hr.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 10
Additional information
A summary report (NTP, 1996) presents a review of the literature, and NTP-derived data, which documents that 1,4-butanediol (BDO) and γ-butyrolactone (GBL) are both metabolized to γ-hydroxybutyric acid (GHB). The pharmacologic and toxicologic responses to these chemicals are due to this metabolite, or more likely, due to GHB's further metabolism to the neurotransmitter, gamma-aminobutyric acid (GABA). Within 72 hours of oral administration of BDO in rats, approximately 94% was excreted as carbon dioxide in exhaled breath, with appoximately 50% within the first 2 hours. Excretion in urine and feces was approximately 4% and 0.6%, respectively, and the amount remaining in the carcass after 72 hours was 2.28%, with the largest amounts present in liver, muscle, and skin. It has been estimated that approximately 10% of a dose applied percutaneously is absorbed in the rat (Fung, HA, Lettieri, J.T., and Bochner, R. (1979). Percutaneous butyrolactone absorption in rats. J. PharmacoL Sci 68, 1198 -1200).
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