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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
other: Human case
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
other: Any kind of reliability rating is not considered to be applicable, since human studies/reports are not conducted/reported according to standardised guidelines.
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
(i) Significant association was only found when correcting for creatinine. However, creatinine correction is known to be particularly difficult if overweight humans are concerned. Since BMI was not used as a confounding factor, data analysis may have led to false findings for parameters for which bodyweight may be considered as a confounding factor. (ii) The concerned range of urinary molybdenum levels can be assumed to reflect the range of biological variation for an ubiquitous occurring essential trace element. Consequently, notable anthropogenic contribution to molybdenum exposure of the study population is not expected. The relevance of this study is therefore assessed as explorative/observational rather than conclusive in terms of observed negative health effects.

Data source

Reference
Reference Type:
publication
Title:
Urinary heavy metals and associated medical conditions in the US adult population
Author:
Mendy, A. et al.
Year:
2012
Bibliographic source:
Int. J. Environ. Health Res. 22, 115-118

Materials and methods

Endpoint addressed:
repeated dose toxicity: oral

Test material

Constituent 1
Chemical structure
Reference substance name:
Molybdenum
EC Number:
231-107-2
EC Name:
Molybdenum
Cas Number:
7439-98-7
Molecular formula:
Mo
IUPAC Name:
molybdenum - dissolved

Method

Details on study design:
Epidemiological retrospective cohort study of sub-sample of adults included in NHANES 2007/2008.

Results and discussion

Results:
Brief summary of findings: Association of molybdenum concentrations in urine and increased incidence of liver conditions.
justification of reliability rating:
(i) Significant association was only found when correcting for creatinine. However, creatinine correction is known to be particularly difficult if overweight humans are concerned. Since BMI was not used as a confounding factor, data analysis may have led to false findings for parameters for which bodyweight may be considered as a confounding factor.
(ii) The concerned range of urinary molybdenum levels can be assumed to reflect the range of biological variation for an ubiquitous essential trace element. Consequently, notable anthropogenic contribution to molybdenum exposure of the study population is not expected. The relevance of this study is therefore assessed as explorative/observational rather than conclusive in terms of observed negative health effects.

Applicant's summary and conclusion

Conclusions:
For its missing consideration of using bodyweight as a confounding factor, the conducted data analysis is assessed not suitable to correctly investigate into associations between urinary molybdenum levels and any health impact. The observed range of molybdenum levels reflect natural variation and can therefore not be used to reliably detect a dose-response relationship.