Registration Dossier
Registration Dossier
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EC number: 203-632-7 | CAS number: 108-95-2
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature
Data source
Reference
- Title:
- No information
- Author:
- DHEW/NIOSH (1976): Criteria for a recommended standard -|occupational exposure to phenol. Report. Department of|Health, Education and Welfare, Washington/DC, NTIS PB|266495.
Materials and methods
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- Review
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenol
- EC Number:
- 203-632-7
- EC Name:
- Phenol
- Cas Number:
- 108-95-2
- Molecular formula:
- C6H6O
- IUPAC Name:
- phenol
Constituent 1
Results and discussion
- Results of examinations:
- This review gives a historical overview on human experience following exposure to phenol. Liquid phenol in contact with the skin rapidly enters the bloodstream. From a variety of case reports clinical signs are known being documented for various occupationally exposed persons. These signs and symptoms can develop rapidly with serious consequences including shock, collapse, coma, convulsions, cyanosis, damage to internal organs, and death. Skin contact of humans with solutions, emulsions, or preparations containing 80-100% phenol for 5-30 minutes has been reported to result in death.
Any other information on results incl. tables
This review gives a historical overview on human experience following exposure to phenol. Liquid phenol in contact with the skin rapidly enters the bloodstream. From a variety of case reports clinical signs are known being documented for various occupationally exposed persons. These signs and symptoms can develop rapidly with serious consequences including shock, collapse, coma, convulsions, cyanosis, damage to internal organs, and death. Skin contact of humans with solutions, emulsions, or preparations containing 80-100% phenol for 5-30 minutes has been reported to result in death.
Applicant's summary and conclusion
- Conclusions:
- Classification: corrosive (causes burns)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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