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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Non-GLP, non-guideline, animal experimental study, only brief summary available, acceptable with restrictions.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Principles of method if other than guideline:
The toxicity of vinyl acetate was assessed following dermal exposure of rabbits.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Vinyl acetate
EC Number:
203-545-4
EC Name:
Vinyl acetate
Cas Number:
108-05-4
Molecular formula:
C4H6O2
IUPAC Name:
ethenyl acetate
Radiolabelling:
no

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
Single application, no data regarding duration
Doses:
4, 8, 16 mL/kg bodyweight
No. of animals per group:
4
Details on study design:
Vinyl acetate (undiluted) was applied dermally under Vinylite covering. Animals were placed in a hood with their heads protruding into the room to prevent the inhalation of vapour.

Results and discussion

Signs and symptoms of toxicity:
yes
Remarks:
see table below
Dermal irritation:
yes
Remarks:
see table below
Absorption in different matrices:
Systemic toxicity and gross pathology following occluded dermal exposure demonstrates absorption.

Any other information on results incl. tables

Dose

mL/kg

Dead/dosed

Days to death

Weight change

Skin condition

Signs/Symptoms

16.0

4/4

0,0,0,0

-

Brownish

Convulsions within 15-30 minutes. Crying. Pupils turned upwards. Dead within 25-70 minutes.

8.0

2/4

1,2

-230, +44

Erythema, oedema, necrosis

 

4.0

0/4

-

-320, +24,

+132, +284

 

 

Gross pathology – congestion of the lungs and liver; spleen and kidney mottled; liver acini prominent.

LD50 - 8.00 mL undiluted vinyl acetate/kg.

Applicant's summary and conclusion