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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Case study with limited information on individual patient who ingested phosphoric acid.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1980

Materials and methods

Study type:
clinical case study
Endpoint addressed:
not applicable
Principles of method if other than guideline:
Patients who ingested liquid caustics were reviewed for location, extent, severity, and outcome of the mucosal injury.
GLP compliance:
no

Test material

Constituent 1
Details on test material:
- Name of test material (as cited in study report): phosphoric acid

Method

Subjects:
- Number of subjects exposed: 1
- Sex: male
- Age: 42 years
- Race: no data
- Demographic information: no data
- Known diseases: no data
Route of exposure:
oral
Reason of exposure:
other: suicide attempt
Exposure assessment:
not specified

Results and discussion

Clinical signs:
In the patient who ingested phosphoric acid, hematemesis and oral pharyngeal burns were observed.
Extent and severity of injury - Endoscopy and/or surgery: moderate distal esophagitis (esophagus), severe proximal gastritis (stomach), normal duodenum.

Any other information on results incl. tables

The patient was unavailable for follow-up.

Applicant's summary and conclusion

Conclusions:
In the patient who ingested 240 mL phosphoric acid, hematemesis and oral pharyngeal burns were observed.
Extent and severity of injury - Endoscopy and/or surgery: moderate distal esophagitis (esophagus), severe proximal gastritis (stomach), normal duodenum.