Registration Dossier

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary reference - Article from original source not retrieved - based on Payne review
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1977

Materials and methods

Type of sensitisation studied:
skin
Study type:
study with volunteers
GLP compliance:
not specified

Test material

Constituent 1
Details on test material:
Phosphoric acid

Method

Type of population:
not specified
Route of administration:
dermal

Results and discussion

Results of examinations:
From Payne review: Stinging sensations following facial application of phosphoric acid during profuse sweating have been studied (Frosch and Kligman 1977). In the c.20% of individuals who demonstrated a high susceptibility to such effects, identified by reactions to topically applied lactic acid, an immediate but transient, generally mild to moderate, stinging response was experienced within the first 10 seconds of exposure to 5% phosphoric acid followed by a more severe stinging sensation 2-5 minutes after exposure. A similarly severe response was experienced on application of 3 ,3% solutions while application ol 1% solutions produced only a slight response. For "non-stingers" 5% phosphoric acid produced a generally mild-moderate stinging sensation 2.5 minutes after exposure. The intensity of stinging and obseruable irritant reactions for a range of chemicals was reported not to be directly correlated.

Applicant's summary and conclusion