Registration Dossier

Administrative data

Description of key information

Acute toxicity: oral
An oral LD50 of 1.70 mL/100 g body weight in SPF-Wister K rats for a 10% solution of 75.4% thermal phosphoric acid was observed
Acute toxicity: inhalation
No reliable data on phosphoric acid are available for the inhalation route of exposure.
Acute toxicity: dermal
No reliable data are available for the dermal route of exposure.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 600 mg/kg bw

Additional information

Acute toxicity: oral

The laboratory for Commercial and Pharmaceutical Toxicology (1968) observed an LD50 of 1.70 ml/100 g body weight

in SPF-Wister K rats for a 10% solution of 75.4% thermal phosphoric acid (study performed according to OECD Guideline 423). Acute toxicity: inhalation No reliable data are available for phosphoric acid. Acute dermal toxicity Phosphoric acid is classified as corrosive to the skin. There is no concern for the dermal route of exposure as personal protective equipment is used (gloves and googles) in the production and use of phosphoric acid. In addition key studies are available for acute oral toxicity and acute inhalation toxicity. Therefore, there is no need to perform an acute dermal toxicity test with phosphoric acid according to the REACH Regulation (column 2 adaptation, Annex VIII, section 8.5).

Justification for classification or non-classification

As the acute oral LD50 > 2600 mg/kg bw, phosphoric acid should not be classified according to the CLP Regulation (EC) No 1272/2008 for this endpoint.