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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Abstract only; insufficient number of animals tested, no information on test conditions and scope of investigation per animal

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Details on test material:
-Name: Orthophosphoric acid

Test animals

Species:
rabbit
Strain:
New Zealand White

Administration / exposure

Type of coverage:
semiocclusive
Duration of exposure:
24 hours
Doses:
631-7490 mg/kg bw
No. of animals per sex per dose:
1 or 2/dose (no info on gender)

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 1 260 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 85% aqueous solution of phosphoric acid
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 160 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 80% aqueous solution of phosphoric acid
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 160 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 75% aqueous solution of phosphoric acid

Any other information on results incl. tables

Clinical signs included reduced appetite and activity, increasing weakness, collapse and death. Viscera of surviving animals appeared normal at autopsy

Applicant's summary and conclusion

Interpretation of results:
other: The reported LD50 values for 85, 80 and 75% aqeous solution of phosphoric acid were >1260, >3160 and >3160 mg/kg bw, respectively.
Remarks:
Criteria used for interpretation of results: not specified
Conclusions:
The reported LD50 values for 85, 80 and 75% aqeous solution of phosphoric acid were >1260, >3160 and >3160 mg/kg bw, respectively.