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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Short summary of primary study.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1983

Materials and methods

Principles of method if other than guideline:
Chronic inhalation of hydro-aerosol of phopshoric acid in a concentration of 10.6 mg/m3 per P2O5.
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Details on test material:
- Name of test material (as cited in study report): phosphoric acid
- Other: administered as hydro-aerosol of phosphoric acid expressed as per P2O5

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remarks on MMAD:
MMAD / GSD: No data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
No data
Frequency of treatment:
No data
Doses / concentrations
Remarks:
Doses / Concentrations:
10.6 mg/m3
Basis:
other: concentration per P2O5
No. of animals per sex per dose:
NO data
Control animals:
not specified

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

The chronic inhalation of hydro-aerosol of phosphoric acid in a concentration of 10.6 mg/m3 per P2O5 resulted in the dysfunction of rats' liver (i.e. reduction of glycogen in liver and of albumin in blood serum), increased levels of inorganic phosphorus in blood and the increase in a relative weight of lungs, kidneys and spleen.

From morphological point of view, the animals developed the progressive bronchitis which resulted in the deformation of bronchi walls and the development of bronchiectasis. In addition, it was registered that there were dystrophic changes of hepatocytes in liver; epithelial degeneration of convoluted tubules in kidneys; and hyperemia and increased malpighian corpuscles in spleen.

Applicant's summary and conclusion

Conclusions:
The chronic inhalation of hydro-aerosol of phosphoric acid in a concentration of 10.6 mg/m3 per P2O5 resulted in the dysfunction of rats' liver (i.e. reduction of glycogen in liver and of albumin in blood serum), increased levels of inorganic phosphorus in blood and the increase in a relative weight of lungs, kidneys and spleen.
From morphological point of view, the animals developed the progressive bronchitis which resulted in the deformation of bronchi walls and the development of bronchiectasis. In addition, it was registered that there were dystrophic changes of hepatocytes in liver; epithelial degeneration of convoluted tubules in kidneys; and hyperemia and increased malpighian corpuscles in spleen.