Registration Dossier
Registration Dossier
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EC number: 215-215-7 | CAS number: 1313-99-1
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Adequacy of study:
- supporting study
- Rationale for reliability incl. deficiencies:
- other: A summary of direct observation data is provided in the Executive Summary.
Data source
Materials and methods
Test material
- Reference substance name:
- Nickel monoxide
- EC Number:
- 215-215-7
- EC Name:
- Nickel monoxide
- Cas Number:
- 1313-99-1
- Molecular formula:
- NiO
- IUPAC Name:
- oxonickel
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
ENDPOINT SUMMARY:
Following an extensive literature search, only a single study was identified characterizing clinical cases, poisoning incidents, and other direct observations in humans. This study reported on nineteen case studies of male steelworkers employed as deseamers of steel ingots, identifying pulmonary dysfunction and signs of pneumoconiosis among workers exposed to nickel oxide (Jones and Warner 1972). The authors concluded that because workers were exposed to compounds other than iron, siderosis was not an appropriate diagnosis and rather suggested that the correct diagnosis was mixed-dust pneumoconiosis and the loss of pulmonary function was caused by the effects of the mixture of metallic oxides. Though the findings of this study are informative, they are not sufficient to fully characterize this endpoint.
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