Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-173-7 | CAS number: 79-06-1
Toxicological information
Acute Toxicity: inhalation
Currently viewing:
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)
- Deviations:
- not specified
- GLP compliance:
- no
- Remarks:
- Pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Acrylamide
- EC Number:
- 201-173-7
- EC Name:
- Acrylamide
- Cas Number:
- 79-06-1
- Molecular formula:
- C3H5NO
- IUPAC Name:
- prop-2-enamide
- Details on test material:
- - Name of test material (as cited in study report): 50% acrylamide
- Substance type: organic
- Physical state: liquid (aqueous solution)
- Analytical purity: not specified
- Impurities (identity and concentrations): not specified
- Composition of test material, percentage of components: 49±2% w/w in solution
- Isomers composition: not applicable
- Purity test date: 07/05/1975
- Lot/batch No.: MM04115-7
- Expiration date of the lot/batch: not specified
- Stability under test conditions: stable
- Storage condition of test material: not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not specified
- Age at study initiation: not specified
- Weight at study initiation: 265-279 g
- Fasting period before study: not specified
- Housing: singly
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: not specified
ENVIRONMENTAL CONDITIONS
- Temperature (°C): room temperature
- Humidity (%): not specified
IN-LIFE DATES: 15/05/1975 to 29/05/1975
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: glass chamber
- Exposure chamber volume: 160 litres
- Method of holding animals in test chamber: restricted chamber volume
- Source and rate of air: 50 litres/minute by positive pressure spray nozzle
- Method of conditioning air: not specified
- System of generating particulates/aerosols: not specified
- Method of particle size determination: Royco particle analyser/light scattering
- Treatment of exhaust air: not specified
- Temperature, humidity, pressure in air chamber: not specified
TEST ATMOSPHERE
- Brief description of analytical method used: nominal
- Samples taken from breathing zone: no
VEHICLE: Substance was tesed as an aqueous solution
TEST ATMOSPHERE
- Particle size distribution: 1.95 microns (mean value) with 99% of particles 6 microns or smaller
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 2.95 - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- 12 mg of test substance/litre
- No. of animals per sex per dose:
- 6 males !one dose)
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 15/5, 16/5, 19/5, 21/5, 23/5, 28/5, 29/5
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight - Statistics:
- None
Results and discussion
- Preliminary study:
- None
Effect levels
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 12.1 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- One animal died as a result of an infection unrelated to chemical exposure.
- Clinical signs:
- other: No visible lesions could be attributed ot the test material.
- Body weight:
- No effects could be attributed ot the test material.
- Gross pathology:
- Not performed.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The results of this test indicate that the 50.7% solution of acrylamide is practically non-toxic by the inhalation route with a LC0 of 12 g/m3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
