Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acrylamide induces peripheal neuropathy charcterized by a dying back of neurons. The NOAEL for this effect is 0.5 mg/kg/day as determined by light and electron microscopy.  No clincal effects were obseved at 2.0 mg/kg/day, the next highest dose.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
0.5 mg/kg bw/day
Study duration:

Additional information

Repeated dose toxicity: via oral route - systemic effects (target organ) neurologic: periphreal nerve

Justification for classification or non-classification