Registration Dossier
Registration Dossier
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EC number: 203-625-9 | CAS number: 108-88-3
Toxicity to soil microorganisms
Administrative data
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Information from a published review article, reliability not known but contributing to a weight of evidence assessment
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Integrated criteria document toluene effects.
- Author:
- Heijden CA van der, Mulder HCM, de Vrijer F, Woutersen RA, Davis PB, Vink GJ, Heijna-Merkus E, Janssen PJCM, Canton JH, van Gestel CAM
- Bibliographic source:
- National Institute of Public Health and Environmental Protection (RIVM), Appendix to Report 758473010, Bilthoven, The Netherlands.
Materials and methods
- Principles of method if other than guideline:
- method not reported
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test organisms
- Test organisms (inoculum):
- soil
Study design
- Total exposure duration:
- 28 d
Test conditions
- Test temperature:
- 20°C
- Details on test conditions:
- Loam and humic soil tested
Results and discussion
Effect concentrations
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 26 mg/kg soil dw
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: nitrification
- Remarks on result:
- other: both soils
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 28 day NOEC for inhibition of nitrification in two soils was <26mg/kg soil dry weight.
- Executive summary:
The data presented here is taken from the review article by Heijden et al (1988) so we are unable to evaluate its reliability. However, this enpoint was used in the EU RAR for toluene.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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