Registration Dossier
Registration Dossier
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EC number: 289-339-5 | CAS number: 87741-01-3
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: gene mutation
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other:
Data source
Referenceopen allclose all
- Reference Type:
- other: EU Risk Assessment
- Title:
- European Union Risk Assessment Report 1,3-BUTADIENE, CAS No: 106-99-0, EINECS No:203-450-8
- Author:
- [ECB] European Chemicals Bureau
- Year:
- 2 002
- Reference Type:
- publication
- Title:
- Genotoxic activity of 1,3-butadiene and nitrogen dioxide and their photochemical reaction products in Drosophila and in the mouse bone marrow micronucleus assay.
- Author:
- Victorin, K. et al.
- Year:
- 1 990
- Bibliographic source:
- Mutat Res. 228; 203-209.
Materials and methods
- Principles of method if other than guideline:
- EU Risk Assessment on the major component of C4 Hydrocarbons: 1,3-Butadiene
- Type of assay:
- somatic mutation and recombination test in Drosophila
Test material
- Reference substance name:
- Buta-1,3-diene
- EC Number:
- 203-450-8
- EC Name:
- Buta-1,3-diene
- Cas Number:
- 106-99-0
- Molecular formula:
- C4H6
- IUPAC Name:
- buta-1,3-diene
- Details on test material:
- - Name of test material (as cited in study report): 1,3-butadiene
Constituent 1
Test animals
- Species:
- Drosophila melanogaster
Results and discussion
Test results
- Genotoxicity:
- negative
Any other information on results incl. tables
There is one study reported of a somatic mutation and recombination test in Drosophila melanogaster (Victorin et al., 1990). There was no significant difference in the number of wing spots between the butadiene exposed group and control, indicating that butadiene is not mutagenic in this test system.
Applicant's summary and conclusion
- Executive summary:
Butadiene is not mutagenic in Drosophila.
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