Registration Dossier

Administrative data

Endpoint:
mechanistic studies
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Nonrelevant test system

Data source

Reference
Reference Type:
publication
Title:
Evaluation of nickel toxicity on liver, spleen, and kidney of mice after administration of high-dose metal ion.
Author:
Pereira, M.C., M.L. Pereira, and J.P. Sousa.
Year:
1998
Bibliographic source:
Journal of Biomedical Materials Research. 40:40-47.

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Type of method:
in vivo
Endpoint addressed:
repeated dose toxicity: dermal

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Frequency of treatment:
4 weeks

Results and discussion

Applicant's summary and conclusion

Executive summary:

STUDY RATED BY AN INDEPENDENT REVIEWER