Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Currently viewing:

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: observational study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Provided for informational purposes
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Acute nickel intoxication by dialysis.
Author:
Webster JD, Parker TF, Alfrey AC, Smythe WR, Kubo H, Neal G, Hull AR.
Year:
1980
Bibliographic source:
Ann. Intern. Med. 92: 631-633.

Materials and methods

Study type:
clinical case study
Endpoint addressed:
not applicable
Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Clinical signs:
Nausea, vomiting, weakness, headache, and palpitations were observed after iatrogenic exposure of 23 patients to high levels of nickel during
haemodialysis due to leaching from a nickel-plated, stainless steel, water heating tank. The symptoms were observed at plasma nickel
concentrations of approximately 3 mg Ni/l and disappeared upon cessation of dialysis.

Applicant's summary and conclusion

Conclusions:
Nausea, vomiting, weakness, headache, and palpitations were observed after iatrogenic exposure of 23 patients to high levels of nickel during haemodialysis due to leaching from a nickel-plated, stainless steel, water heating tank. The symptoms were observed at plasma nickel concentrations of approximately 3 mg Ni/l and disappeared upon cessation of dialysis.
Executive summary:

STUDY RATED BY AN INDEPENDENT REVIEWER.