Registration Dossier

Administrative data

Description of key information

Value used for CSA:

Skin irritation / corrosion: not irritating

Eye irritation: not irritating

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Nickel is not an skin or eye irritant in experimental animals. The skin irritation potential has been examined in a study performed by OECD Guideline 404 (Acute Dermal Irritation / Corrosion) (SLI 1999a). Metallic nickel gave only slight irritation (erythema) in the test. There is no reason to suggest that nickel metal should be classified for irritation or corrosivity to skin.

No studies of eye irritation by metallic nickel have been found for nickel metal. For this endpoint the putative toxicant would be the nickel ion, and consequently the toxicity would be related to the amount of free ion. Therefore, toxicity data from water-soluble nickel compounds can be used to estimate the potential of nickel metal to cause eye irritation. NiSO4 has been tested by OECD Guideline 405 (Acute Eye Irritation / Corrosion) and no classification for eye irritation is proposed for NiSO4.

The following information is taken into account for any hazard / risk assessment:

SKIN: Metallic nickel gave only slight irritation in an animal study (SLI 1999a). There are no data to suggest that nickel metal should be classified for irritation or corrosivity to skin.

EYE: No studies of eye irritation by metallic nickel have been found. Toxicity data from water-soluble nickel compounds can be used to estimate the potential of Ni ions released from nickel metal to cause eye irritation. No classification for eye irritation is proposed for NiSO4, and hence the Ni ions released from Ni metal, based on the results from an animal study. However, physical irritation by the particles (i.e. particle effect) cannot be ruled out with this read-across.

Value used for CSA:

Skin irritation / corrosion: not irritating

Eye irritation: not irritating

Justification for classification or non-classification

Ni metal is not classified for dermal or eye irritation in the 1st ATP to the CLP Regulation. Background information has been provided in the discussion section above.