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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

skin sensitisation
other: epidemiological assessment
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study results of this epidemiological study apply for cement, a product which is about a factor of 20 to 100 more prevalent than Flue dust.

Data source

Reference Type:
review article or handbook

Materials and methods

Test guideline
no guideline followed
Principles of method if other than guideline:
epidemiological assessment
GLP compliance:
not specified
Type of study:
other: epidemiological review

Test material

Constituent 1
Reference substance name:
Cement, portland, chemicals
EC Number:
EC Name:
Cement, portland, chemicals
Cas Number:
Constituent 2
Reference substance name:
cement clinker production and application
cement clinker production and application

Results and discussion

In vivo (non-LLNA)

other: epidemiological assessment
Dose level:
not applicable
Remarks on result:
other: Reading: other: epidemiological assessment. Dose level: not applicable.

Any other information on results incl. tables

The endpoint study record describes the results of an epidemiological study and not the results of a test.

Applicant's summary and conclusion

The available epidemiological literature provides documentation that supports the hypothesis of a relationship between Cr(VI) in wet cement and allergic dermatitis in construction workers.
Executive summary:

Chromium, especially hexavalent chromium, is a well known skin sensitiser, and it is assumed th sensitisation reactions in cement workers are the result of the content of hexavalent chromium in cement. Some countries have since the 1980s had legislation which regulates the concentration of the chromium in the cement. A decline in the occurence of cement induced chromium allergy which have been reported during the last 20 -30 years have been attributed to this measure. However, the epidemiological evidence for such a relationship has been questioned. therefore this review of the available epidemiological literature on chromium allergy related to wet cement was carried out. The following two questions were adressed specifically:

- Does Cr(VI) in wet cement cause allergic dermatitis in construction workers?

- Is there any causal association between the reduction of Cr(VI) in cement and the occurence of allergic dermatitis?

The available epidemiological literature supports the hypothesis of a relationship between the chromium (i.e. Cr(VI)) in wet cement and allergic dermatitis in construction workers. there was not found epidemioligical evidence to conclude that there is a causal association between the reduction of Cr(VI) in cement and the reduced occurence of allergic dermatitis. However, although the documentation is relatively sparse, the available documentation indicates such a relationship.