Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-466-5 | CAS number: 107-13-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published mechanistic study reporting acute LD50 values
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity of some synthetic cyanogens in rats: Time-dependent cyanide generation and cytochrome oxidase inhibition in soft tissues after sub-lethal oral intoxication
- Author:
- Rao P, Singh P, Kumar Yadav S, Gujar NL & Bhattacharya R
- Year:
- 2 013
- Bibliographic source:
- Food and Chemical Toxicology 59: 595–609
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Dixon’s up and down method
- GLP compliance:
- no
- Remarks:
- published study
- Test type:
- up-and-down procedure
- Limit test:
- no
Test material
- Reference substance name:
- Acrylonitrile
- EC Number:
- 203-466-5
- EC Name:
- Acrylonitrile
- Cas Number:
- 107-13-1
- Molecular formula:
- C3H3N
- IUPAC Name:
- prop-2-enenitrile
Constituent 1
- Specific details on test material used for the study:
- Not reported
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Rats were gavaged with acrylonitrile
- No. of animals per sex per dose:
- 6-8 rats were used in total
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 95.1 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 81.7 - <= 110.6
- Remarks on result:
- other:
- Remarks:
- An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported.
Any other information on results incl. tables
An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported.
- Executive summary:
The oral LD50 of acrylonitrile was investigated preliminary to mechanistic investigations. 6 -8 female Wistar rats were administered acrylonitrile by gavage according to Dixon’s up and down method. An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported. This value is consistent with other data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
