Registration Dossier

Administrative data

Description of key information

In vivo studies show that the substance is a mild skin and eye irritant but is not corrosive, and is not classified according to current criteria.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation

The skin irritation and corrosion potential of terephthalic acid has been investigated in three studies. The results of a guideline-comparable study (with 24 -hour application) show minimal irritant effects on intact skin (Baker, 1975). No evidence of corrosivity was seen in a screening study (DuPont, 1981). The results of an irritation study reported in summary form only (Hatoum & Goun, 1990) are also consistent in indicating a very low potential for dermal irritation.

Eye irritation

A single eye irritation study is available (Baker, 1975), in which 100 mg undiluted terephthalic was applied to the eyes of albino rabbits. One rabbit showed a stronger reaction than the others, but in all cases eyes had returned to normal within 48 hours. Effects were limited to Grade 1 conjunctival erythema and chemosis in all rabbits, with Grade 1 corneal opacity also apparent in one rabbit at 24 hours only. Conjunctival discharge was additionally noted in one rabbit at 24 hours only. Mild irritation was seen in a guideline-comparable study.


Justification for selection of skin irritation / corrosion endpoint:
Guideline compliant study

Justification for selection of eye irritation endpoint:
Only study available for this endpoint

Justification for classification or non-classification

The available studies indicate that terepththalic acid is not classified as a skin or eye irritant, or as corrosive, according to CLP.