Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

No data are available for TPA, however a negative Buehler study is reported for the read-across substance isophthalic acid (IPA). The OECD QSAR Toolbox does not report any structural alerts for protein binding activity (relevant for skin sensitisation) for TPA or IPA. TPA (benzene-1,4 -dicarboxylic acid) and IPA (benzene-1,3 -dicarboxylic acid) are structurally highly similar (isomers), differing only in the position of the two carboxylic acid sidechains on the benzene ring. As such, the potential for protein binding is likely to be comparable fo the two substances and read-across for the skin sensitisation endpoint is scientifically justified.


Migrated from Short description of key information:
No evidence of skin sensitisation was noted in a Buehler study with the read-across compound isophthalic acid (IPA). The OECD QSAR Toolbox does not report any structural alerts for protein binding activity (relevant for skin sensitisation) for TPA.

Justification for selection of skin sensitisation endpoint:
Only one study is available for this endpoint.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

No classification for skin sensitisation is proposed on the basis of a negative Buehler study with the read-across substance isophthalic acid.