Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: Data sharing dispute
Adequacy of study:
key study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: According to the OECD SIDS document for sodium hydroxide (March 2002), a Klimisch 3 reliability score was assigned since documentation is insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
No title available
Author:
Naunyn-Schmiedeberg's
Year:
1937
Bibliographic source:
Archiv für experimentielle Pathologie und Pharmakologie (Berlin, Germany), 184, 587-604

Materials and methods

Principles of method if other than guideline:
other (not specified)
GLP compliance:
no
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium hydroxide
EC Number:
215-185-5
EC Name:
Sodium hydroxide
Cas Number:
1310-73-2
Molecular formula:
HNaO
IUPAC Name:
sodium hydroxide
Details on test material:
no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 2500-3500 g

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 160-940 mg/kg bw
MAXIMUM DOSE VOLUME APPLIED: 4.9-31 ml/kg body weight
No. of animals per sex per dose:
46 animals (no data for sex)
Control animals:
not specified
Statistics:
not described

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
325 mg/kg bw

Applicant's summary and conclusion