Registration Dossier
Registration Dossier
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EC number: 215-185-5 | CAS number: 1310-73-2
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation, other
- Remarks:
- not specified
- Type of information:
- other: Data sharing dispute
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: According to the OECD SIDS document for sodium hydroxide (March 2002), a Klimisch 4 reliability score was assigned since the original reference is not available.
Data source
Reference
- Reference Type:
- publication
- Title:
- No title available
- Author:
- Dluhos et al.
- Year:
- 1 969
- Bibliographic source:
- cited in: Martin FM, Report EPA/600/8-88/081, Order-No. PB88-231949, 1988
Materials and methods
- Principles of method if other than guideline:
- other: not specified
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Sodium hydroxide
- EC Number:
- 215-185-5
- EC Name:
- Sodium hydroxide
- Cas Number:
- 1310-73-2
- Molecular formula:
- HNaO
- IUPAC Name:
- sodium hydroxide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 10 weeks
- Frequency of treatment:
- 20 min., twice weekly
Doses / concentrations
- Remarks:
- Doses / Concentrations:
40% (dispersed aerosol)
Basis:
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: not specified
Results and discussion
Results of examinations
- Details on results:
- Bronchial epithelium was sometimes wrinkeled, sometimes flattened and in places ulcerated and necrotic; the peribronchial lymphadenoid tissue was hypertrophic and extruded cushion-like into the bronchial lumen, causing slit-like deformities.
Effect levels
- Remarks on result:
- other: no details reported
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
