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EC number: 200-659-6 | CAS number: 67-56-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
In studies for skin and eye irritation, no adverse effects were observed for rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Study performed according to internal company standards (BASF-test) before actual guideline was adopted.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: unspecified amount
- Concentration: 100 % (undiluted) - Duration of treatment / exposure:
- 1, 5, 15 min and 20 hours (ear: only 20 hours)
- Observation period:
- 24, 48, 72 hours, 6 days and 8 days after beginning of application (exception: application time 20 hours: no observations after 24 hours)
- Number of animals:
- 2 (1, 5 and 15 min); 2 (20 hours)
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm area of skin on the back and the ear
- % coverage: not specified (application site 2.5 x 2.5 cm)
- Type of wrap if used: cotton pad soaked with the undiluted test substance, covered by an impervious bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water, sometimes containing a mild detergent
- Time after start of exposure: 1, 5, 15 min, 20 hours (after the application)
SCORING SYSTEM: BASF scoring system, convertible to Draize - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effect
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effect
- Irritant / corrosive response data:
- After 1, 5, 15 min of exposure, no signs of irritation (erythemy, edema) were apparent after 24, 48 and 72 hours and after 6 and 8 days. After 20 hours of exposure no signs of irritation (erythema, edema) were apparent after 48 and 72 hours and after 6 and 8 days
- Other effects:
- No mortality occurred. There were no clinical signs of systemic toxicity from the dermal exposure.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
Reference
No individual animal scores given in the report
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- limited documentation
- Principles of method if other than guideline:
- Study performed according to internal company standards (BASF-test) before actual guideline was adopted.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: saline-treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.05 ml
- Concentration (if solution): 100 % - Duration of treatment / exposure:
- unspecified (not rinsed)
- Observation period (in vivo):
- 1 hour, 24 hours, 8 days (no further time points reported)
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): not rinsed
SCORING SYSTEM: BASF-code, convertible to DRAIZE
TOOL USED TO ASSESS SCORE: no data - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritant / corrosive response data:
- After 1 h, mild erythema and cornea opacity as well as moderate edema associated with secretion were observed. After 24 h, the effects were assessed as mild. After 8 days the animals were without symptoms.
- Other effects:
- not reported
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
Reference
This screening test gave evidence of mild to moderate irritation of the mucous membrane on contact with pure methanol, which was fully reversible within 8 days. Therefore, there was no need for classification as eye irritating.
Exposure to an atmosphere saturated by methanol vapours at 20°C produced severe irritation of mucous membranes and milky corneal opacity in rats (time not specified) and eventually led to mortality of all animals within 8 h.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin:
The irritation potential of an unspecified dose of undiluted methanol in rabbits was examined under occlusive conditions after exposure intervals of 1, 5, and 15 minutes and 20 hours. According to Draize scoring, no signs of skin irritation were observed 24 hours and 8 days after treatment for any of the exposure time periods (BASF, 1975).
Eye:
One hour after instillation of 0.05 mL undiluted methanol into the eyes of two rabbits, slight erythemas and corneal opacity as well as moderate edemas associated with secretion were observed. After 24 hours, the effects were assessed as mild, and after 8 days the animals had no symptoms (BASF, 1975).
In another study, mild to moderate conjunctivitis and edemas as well as mild iritis were produced in six rabbits after instillation of 0.1 mL undiluted methanol into the eyes. Average scores after 24, 48, and 72 hours were approximately 2 for conjunctivae and < 1 for other effects. Primary irritation subsided after 72 hours, although redness of the conjunctivae persisted at that time. Information on effects after 8 and 14 days was not available (Jacobs, 1990).
Exposure of rats to an atmosphere saturated by methanol vapours at 20 °C produced severe irritation of mucous membranes and milky corneal opacity (time not specified) and eventually led to mortality of all animals within 8 hours (BASF, 1975). This was an additional observation and is not applicable for evaluation of irritant effects. Therefore, it is not relevant for classification.
Justification for classification or non-classification
Classification,
Labelling, and Packaging Regulation (EC) No 1272/2008
The
available experimental test data are reliable and suitable for
classification purposes under Regulation (EC) No 1272/2008. No skin or
eye irritation was observed. As a result the substance is not considered
to be classified for acute oral toxicity under Regulation (EC) No
1272/2008, as amended for the tenth time in Regulation (EU) No 2017/776.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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